Chairs | AI for Integrative Computational Medicine

• Medical Data Lab (UCA Idex) 
• Health Data Hub, EDS APHP 
• International databases 
• Security, privacy, GDPR 
• In collaboration with other 3IA institutes 

Sebastien Ourselin is Head of School of Biomedical Engineering & Imaging Sciences, Professor at King’s College London and Director of the EPSRC Image-Guided Therapies UK Network+. He published more than 400 articles (h-index: 64). He is associate editor for IEEE Tr. on Med Imaging,J of Med Imaging, Nature Scient. Reports, and Medical Image Analysis.

He works on the research topic AI for Healthcare & Image-guided Interventions.

AI for e-patients and e-medicine (2019-2023 / 2023-2027)

We design and exploit modern AI methods: (i) to personalize the parameters of advanced models of the e-patient, (ii) to drive e-medicine algorithms on personalized e-patients (i.e. digital twins) for automated diagnosis, prognosis and therapy, in an efficient, robust, safe and explainable manner.

Video analytics for human behavior understanding (2019-2023 / 2023-2027)

Video analytics enables us to measure objectively the behavior of humans by recognizing their everyday activities, their emotion, eating habits and lifestyle. Human behavior can be modeled by learning from a large quantity of data from a variety of sensors to improve and optimize, for instance, the quality of life of people suffering from behavior disorders. 

Joint biological and imaging biomarkers in oncology (2019-2023 / 2023-2027)

We exploit joint information from imaging and biological data to improve the diagnosis and treatment planning, focusing on lung cancer. This approach relies on methods involving unsupervised deep learning, uncertainty quantification, sparse Bayesian feature selection and the handling of confounding factors.

Comprehensive omics profiling for precision medicine in Oncology (2019-2023 / 2023-2025)

I am combining various patient extracted “omics” data, including multimodal imaging features, for integrative and data-driven computational medicine. I focus on challenging fields in oncology such as (i) radiogenomics and outcome-focused research in metastatic breast cancer and (ii) the accurate prediction of response to immunotherapy. 

Applications of AI for patients with vascular diseases (2021-2024)

Our team develops AI-derived applications for patients with vascular diseases including aortic aneurysm. We aim to create aid-decision support systems to enhance evidence-based decision and precision medicine through a translational approach including: identification of biomarkers, automatization of vascular imaging analysis, development of predictive scores using machine learning.

AI and biophysical models for computational cardiology (2019-2023 / 2023-2027)

The application of AI in healthcare is challenging due to its lack of robustness and explainability. This project aims to introduce physiological priors in AI through biophysical models. This can be done by reformulating problems through such models, by learning spatiotemporal dynamics from biophysics or by augmenting features and data with such simulations.

Ablation: Artificial Intelligence for patient-centered atrial fibrillation ablation (2021-2025)

Atrial fibrillation is the most common sustained arrhythmia in clinical practice and remains the last great frontier of cardiac electrophysiology. The project aims to put forward new AI techniques to help cardiologists perform more effective patient-tailored catheter ablation procedures to treat this challenging cardiac condition.

Learning-based Models in Medical Imaging: Closing the Gap towards Clinical Translation (2021-2024)

We aim to close the gap hindering the translation of AI systems into clinical practice. To this end, we develop novel AI tools for healthcare that 1) learn incrementally as data become available, 2) generalize across multi-modal data and 3) perform quality control of a model and can generate alerts when a decreased in performance is detected.

Global approach to research, development, and global deployment of digital solutions in surgery, with osteoarticular surgery and traumatology as a use case (2024-2028)

The theme developed by Dr. Gauci revolves around computational and augmented medicine & surgery using artificial intelligence tools and the reuse of healthcare data.
Digital surgery merges two complementary aspects:

• Computational surgery, which is fed by patient and imaging data, enabling the creation of 3D/4D geometric and biomechanical models to simulate and plan surgery before it is performed.
• Augmented surgery, which is based on a more or less complex digital model and enables planning to be applied using intraoperative assistance and guidance tools such as 3D printing (model, instrumentation, implant), navigation, robotics or mixed reality including collaborative cloud platform.

Assessing the clinical relevance of these digital solutions alone is not enough to demonstrate their usability and interest in a complex environment such as the operating room or interventional procedure room. The development of models adapted to surgical needs, and the analysis of multiparametric data derived from the use of these models' application tools, should enable us to optimize the integration of these tools in the operating room and in daily practice. Several technology platforms have been set up for experimental and clinical validation such as augmented operating room.